Most genetic defects are lethal in some degree.
In Down's syndrome, patient's experience intellectual disability and flat facies. Their hands possess a single palmar crease.
In Edward's snydrome, the patients experience rocker bottom feet

Clenched hands

prominent occiput

Most common trisomy resulting in live birth after Down syndrome.
Patau syndrome can cause

Cleft lip.

Holoprosencephaly

Polydactyly
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